The first domestic Mass Spectrometer of Bacterial Detection Applied in Clinical Practice

  • 2018-05-26

It is reported that the advanced mass spectrometer, developed by Bioyong Technology Company (BTC), can be used to conduct comprehensive research on bacterial proteomes and genomes. In 2012, it passed the European CEIVD certification and was certified by China food and Drug Administration in 2014. It can rapidly detect and identify gram-negative bacteria which are common pathogenic microorganisms that cause diarrhea, pneumonia, and wound infections in human body.

As is known, gram-negative bacteria are the collective name of various bacteria, including shigella dysenteriae, pneumobacillus bacillus, haemophilus influenzae, bordetella pertussis and other pathogenic bacteria. The use of mass spectrometer to detect bacteria represents a new technology in laboratory medicine. The detection device can accurately and quickly determine the drug resistance of pathogenic bacteria in the body of a patient. Through mass spectrometric analysis of the bacteria, the protein of the bacteria can be identified and it can be accurately determined to which antibiotic the bacteria are resistant, so that doctors can work out a more precise treatment protocol. Otherwise, it may be necessary to try many types of antibiotics when a precise treatment protocol cannot be prepared. As a result, personalized precision treatment can be achieved and the abuse of antibiotics during treatment can be curbed. The detection can be said to be a major breakthrough in domestic mass spectrometers for detection. Peking Union Medical College Hospital has applied the instrument to clinical detection.

In fact, in addition to the medical field, microbiological detection is of great significance in food safety, biosafety and other fields. The BTC, supported by the Special Project of National Major Scientific Instrument and Device Development and in cooperation with Academy of Military Medical Sciences, has established a database containing 2,200 microbial protein fingerprints that can be used to manage microorganisms based on protein fingerprints. It is said that protein fingerprinting is an identifier for each type of microorganism, similar to human fingerprints. Therefore, the establishment of the database is like distributing an identity card to each type bacteria, so that they can be identified accurately, thereby preventing microbial harm to human health.